Design and synthesis of a series of serine derivatives as small molecule inhibitors of the SARS coronavirus 3CL protease
Identifieur interne : 001053 ( Main/Exploration ); précédent : 001052; suivant : 001054Design and synthesis of a series of serine derivatives as small molecule inhibitors of the SARS coronavirus 3CL protease
Auteurs : Hiroyuki Konno [Japon] ; Masaki Wakabayashi [Japon] ; Daiki Takanuma [Japon] ; Yota Saito [Japon] ; Kenichi Akaji [Japon]Source :
- Bioorganic & Medicinal Chemistry [ 0968-0896 ] ; 2016.
Descripteurs français
- KwdFr :
- Bibliothèques de petites molécules (), Bibliothèques de petites molécules (pharmacologie), Bibliothèques de petites molécules (synthèse chimique), Cellules HeLa, Conception de médicament, Cysteine endopeptidases (métabolisme), Humains, Inhibiteurs de protéases (), Inhibiteurs de protéases (pharmacologie), Inhibiteurs de protéases (synthèse chimique), Mort cellulaire (), Protéines virales (antagonistes et inhibiteurs), Protéines virales (métabolisme), Relation dose-effet des médicaments, Relation structure-activité, Simulation de docking moléculaire, Structure moléculaire, Sérine (analogues et dérivés), Sérine (pharmacologie), Sérine (synthèse chimique), Virus du SRAS (enzymologie).
- MESH :
- analogues et dérivés : Sérine.
- antagonistes et inhibiteurs : Protéines virales.
- enzymologie : Virus du SRAS.
- métabolisme : Cysteine endopeptidases, Protéines virales.
- pharmacologie : Bibliothèques de petites molécules, Inhibiteurs de protéases, Sérine.
- synthèse chimique : Bibliothèques de petites molécules, Inhibiteurs de protéases, Sérine.
- Bibliothèques de petites molécules, Cellules HeLa, Conception de médicament, Humains, Inhibiteurs de protéases, Mort cellulaire, Relation dose-effet des médicaments, Relation structure-activité, Simulation de docking moléculaire, Structure moléculaire.
English descriptors
- KwdEn :
- Cell Death (drug effects), Cysteine Endopeptidases (metabolism), Dose-Response Relationship, Drug, Drug Design, HeLa Cells, Humans, Molecular Docking Simulation, Molecular Structure, Protease Inhibitors (chemical synthesis), Protease Inhibitors (chemistry), Protease Inhibitors (pharmacology), SARS Virus (enzymology), Serine (analogs & derivatives), Serine (chemical synthesis), Serine (pharmacology), Small Molecule Libraries (chemical synthesis), Small Molecule Libraries (chemistry), Small Molecule Libraries (pharmacology), Structure-Activity Relationship, Viral Proteins (antagonists & inhibitors), Viral Proteins (metabolism).
- MESH :
- chemical , analogs & derivatives : Serine.
- chemical , antagonists & inhibitors : Viral Proteins.
- chemical , chemical synthesis : Protease Inhibitors, Serine, Small Molecule Libraries.
- chemical , chemistry : Protease Inhibitors, Small Molecule Libraries.
- chemical , metabolism : Cysteine Endopeptidases, Viral Proteins.
- drug effects : Cell Death.
- enzymology : SARS Virus.
- chemical , pharmacology : Protease Inhibitors, Serine, Small Molecule Libraries.
- Dose-Response Relationship, Drug, Drug Design, HeLa Cells, Humans, Molecular Docking Simulation, Molecular Structure, Structure-Activity Relationship.
Abstract
Url:
DOI: 10.1016/j.bmc.2016.01.052
PubMed: 26879854
PubMed Central: 7111485
Affiliations:
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Le document en format XML
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<term>Small Molecule Libraries (pharmacology)</term>
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<term>Viral Proteins (metabolism)</term>
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<author><name sortKey="Fujita Yoshigaki, J" uniqKey="Fujita Yoshigaki J">J. Fujita-Yoshigaki</name>
</author>
<author><name sortKey="Shirouzu, M" uniqKey="Shirouzu M">M. Shirouzu</name>
</author>
<author><name sortKey="Koide, H" uniqKey="Koide H">H. Koide</name>
</author>
<author><name sortKey="Sawada, T" uniqKey="Sawada T">T. Sawada</name>
</author>
<author><name sortKey="Sakiyama, S" uniqKey="Sakiyama S">S. Sakiyama</name>
</author>
<author><name sortKey="Yokoyama, S" uniqKey="Yokoyama S">S. Yokoyama</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Barrett, A J" uniqKey="Barrett A">A.J. Barrett</name>
</author>
<author><name sortKey="Kirschke, H" uniqKey="Kirschke H">H. Kirschke</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lim, I T" uniqKey="Lim I">I.T. Lim</name>
</author>
<author><name sortKey="Meroueh, S O" uniqKey="Meroueh S">S.O. Meroueh</name>
</author>
<author><name sortKey="Lee, M" uniqKey="Lee M">M. Lee</name>
</author>
<author><name sortKey="Heeg, M J" uniqKey="Heeg M">M.J. Heeg</name>
</author>
<author><name sortKey="Mobashery, S" uniqKey="Mobashery S">S. Mobashery</name>
</author>
</analytic>
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</TEI>
<affiliations><list><country><li>Japon</li>
</country>
</list>
<tree><country name="Japon"><noRegion><name sortKey="Konno, Hiroyuki" sort="Konno, Hiroyuki" uniqKey="Konno H" first="Hiroyuki" last="Konno">Hiroyuki Konno</name>
</noRegion>
<name sortKey="Akaji, Kenichi" sort="Akaji, Kenichi" uniqKey="Akaji K" first="Kenichi" last="Akaji">Kenichi Akaji</name>
<name sortKey="Saito, Yota" sort="Saito, Yota" uniqKey="Saito Y" first="Yota" last="Saito">Yota Saito</name>
<name sortKey="Takanuma, Daiki" sort="Takanuma, Daiki" uniqKey="Takanuma D" first="Daiki" last="Takanuma">Daiki Takanuma</name>
<name sortKey="Wakabayashi, Masaki" sort="Wakabayashi, Masaki" uniqKey="Wakabayashi M" first="Masaki" last="Wakabayashi">Masaki Wakabayashi</name>
</country>
</tree>
</affiliations>
</record>
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